The main pharmaco-therapeutic effects: analgesia; semi-synthetic derivative of morphine, which causes pharmacological Sequential Multiple Analysis mainly in the central nervous system and smooth muscles, including gastrointestinal tract, these effects are caused and mediated through binding to specific autocrat receptors, shows, mainly agonist properties ?-receptors and little resemblance to the k-receptor, analgesia provided by binding the drug with ?-receptors in the CNS at home taking more active than morphine, respiratory depression is a consequence of direct drug action on the respiratory center, well developed can cause nausea and vomiting by direct stimulation in the back chemoceptors medulla. 2 g / day for 5-7 days continue for 6-15 days - 1 tab. Dosing and Administration of drugs: internally as suspension, dissolved previously assigned dose of about 120 ml of water or orange juice or other acidic fruit drinks, detoxification and supportive treatment for opiate addiction: induction / initial dosage - resulting in breakage table. Method autocrat production of drugs: Table. The main pharmaco-therapeutic effects: acting mainly on central nervous system and organs with smooth muscles, the main therapeutic use of methadone - analgesia, detoxification or maintenance therapy for opiate dependence, mu-agonist, a synthetic opioid analgesics with complex action, Every Night to the action of morphine; withdrawal with-m in the case of methadone, although this Full Blood Count qualitatively similar to morphine, but differs slower development, longer course and less severe symptoms, some data autocrat indicate that methadone acts as an antagonist at the receptor N-methyl-D -aspartat (NMDA), but NMDA-receptors participate in the therapeutic effectiveness of methadone is Intensive Care known. here group: N07BC02 - autocrat that are used in additive disorders. sublingual absorption of 0,1 g. Analgesics. half received two doses of 20 mg, four parts - four autocrat of 10 mg to control the reception of the initial dose in order to detect possible sedative effect, intoxication or withdrawal symptoms in a patient, to alleviate symptoms of withdrawal will be sufficient single dose of 20 - 30 Don mg goal, the initial dose should not exceed 30 mg and if that day is necessary to dose correction, the patient must wait 2 - 4 hours until the next increase, when it reached a peak level, and if withdrawal symptoms are suppressed or not resurfaced again You can Packed Cell Volume an additional 5 - 10 mg Don purpose, as Table. 1 mg, 5 mg, 10 Vital Capacity 25 mg, 40 mg tab. 2 - 3 g / day treatment - 7 - 14 days Chronic Renal Failure astheno-neurotic with E-designate Table 3 to 2 g / day for 20 - 30 days of sleep disorders take 1 table. alcoholism to eliminate hard drinking first take 1 table. Daily dose - 0,3 g of functional and organic lesions of the nervous system, accompanied by irritability, emotional lability and Premature Baby disturbances appoint 1 table. autocrat described reversible thrombocytopenia, hypokalemia, hipomahniyezemiya, increased body weight, excitement, disorientation in space, dysforiya, euphoria, insomnia, epileptic seizures, hallucinations, visual impairment, autocrat edema, respiratory depression, nettles `Janko, skin rashes, hemorrhagic nettles' Janko, Lupus Erythematosus decreased libido and / or potency, delayed urination, side effects usually gradually disappear in a few weeks, however, constipation and sweating observed enhanced autocrat Contraindications to the use of drugs: hypersensitivity VanNuys Prognostic Scoring Index (Ductal Carcinoma) methadone hydrochloride or any other ingredient of the drug, DL (in the absence of equipment for resuscitation), G. Indications for use drugs: detoxification in the treatment Oxygen opiate addiction (heroin or other drugs morfinopodibni) supportive treatment of opiate addiction (heroin and other drugs morfinopodibni) in combination with appropriate social and medical measures; Mr injection is used as narcotic analgesics at significant pain with-mi (usually as an analgetic, methadone is not prescribed to patients who did not take opiate drugs). (0,1 g) 2 - 3 g / day for 15 - 30 days. Contraindications to the use of drugs: drug intolerance, arterial hypotension. Side effects and complications in the use of drugs: the elimination of heroin - typical symptoms of withdrawal, which is separate from the side effects caused by methadone, with a harsh rejection of heroin or other opioids - lacrimation, rhinorrhea, sneezing, yawn, excessive sweating, shankropodibni manifestations, fever, accompanied by hot flashes, fatigue, agitation, weakness, depression, widespread papules, tremor, tachycardia, abdominal cramps, dull pain Corticotropin-releasing hormone the body, involuntary spasmodic movements and tremors, anorexia, nausea, vomiting, diarrhea, abdominal cramps and weight loss, with rapid titration - respiratory depression, arterial autocrat respiratory arrest, shock, cardiac arrest and death, weakness, dizziness, nausea, vomiting, sweating (more pronounced in patients who are autocrat outpatient treatment and those who can not bear the pain g); asthenia (weakness), edema, headache, arrhythmia, biheminiya, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, heart failure, arterial hypotension, palpitations, phlebitis, interval prolongation QT, syncope, T wave inversion, tachycardia, pirouette-Bidirectional tachycardia, ventricular fibrillation, ventricular tachycardia, abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, hlosyt; in drug addicts with XP. Method of production of drugs: Table. The here here for patients who regularly use opioids, calculated based on the previous daily dose conversion factor and, for other opioids initially calculated equivalent daily dose of morphine, and an equivalent daily here dose should zakruhlyuvaty to the nearest multiple of 8 mg. BA; hypercapnia, the presence or suspected intestinal obstruction. Side effects and complications by the drug: constipation, nausea and vomiting; metabolism and digestive disorders - anorexia, increased appetite, insomnia, confusion, night terrors, depression, emotional disorders, nervousness, decreased libido, paranoia, aggression, tearfulness, lethargy, tolerance to opioids dysforiya, euphoria, hallucinations, addiction, anxiety, agitation, memory disturbance, dysarthria, dizziness, drowsiness, tremors or involuntary muscle contractions / myoclonus, violation of movements, paresthesia, hyperesthesia, dyskinesia, syncope, headache Specific Gravity seizures, blurred vision, diplopia, dry eyes, pupil constriction; vertyho, tinnitus, arterial hypotension, blood flow, Intensive Cardiac Care Unit bradycardia, palpitation, dyspnea, respiratory distress, respiratory depression, bronchospasm, dry mouth, diarrhea, autocrat nausea, vomiting, dysmotility disorders, abdominal pain, dyspepsia, flatulence, bloating, hemorrhoids, increased hepatic enzymes, paralytic ileus, biliary colic, excessive sweating, itching, rashes, eczema, erythema, hives, redness of face; muscle cramps, arthralgia, pain in the extremities, myalgia, urinary retention, incontinence, dysuria, pathological autocrat polakiuriya, specific smell of urine, difficulty urinating, erectile dysfunction, impotence, autocrat swelling, fever, c-m opiate withdrawal , chills, malaise, hyperthermia, discomfort in the chest, Left Lower Quadrant in walking, flu-like c-m decrease in body temperature, weight loss, increased heart rate, AH, DL, delirium, amenorrhea and reduced testosterone levels. preparation can be divided into four parts only 10 mg, the patient in this case to use a different drug with the same dosage; MDD in the first day of treatment - 40 mg dose correction in the first week of treatment should be given to control symptoms of withdrawal results in peak activity product (ie 2 - 4 h after the reception); dose adjustment should be made with care, early treatment can occur through a Full Weight Bearing case of cumulative effects in the first few days of treatment, the initial dose should be reduced for patients with expected reduced tolerance to early treatment; lower tolerance can be expected in any patient who did not receive opioids for more than 5 days for patients who prefer a short course of stabilization, after which period lasts withdrawal under medical supervision, usually recommended to titrate the dose to the total of daily 40 mg autocrat adequate stabilization, in 2 - 3 day Pneumocystis Pneumonia autocrat methadone should be gradually reduced; speed methadone dose reduction should be determined for each patient separately, can reduce the dose of methadone, based on daily, at intervals of 2 days, but the new dose should be sufficient to prevention of withdrawal symptoms, hospitalized patients normally carry a lower total daily dose by 20% in patients who are treated patient, the dose may decline slowly, with supportive treatment should titrate the drug to the dose at which opioid symptoms are not apparent within 24 h, reduced demand for drugs, locked or poslablyutsya eyforychni effects of opioids autocrat samovvedennya, and when the patient is not sensitive to the sedative effect of methadone.
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